Enhanced NO inactivation and hypertension induced by a high-fat, refined-carbohydrate diet.

@article{Roberts2000EnhancedNI,
  title={Enhanced NO inactivation and hypertension induced by a high-fat, refined-carbohydrate diet.},
  author={Christian K. Roberts and Nostarola D Vaziri and Xiao Qi Wang and R. James Barnard},
  journal={Hypertension},
  year={2000},
  volume={36 3},
  pages={423-9}
}
We have recently demonstrated that long-term consumption of a high-fat, refined-carbohydrate (HFS) diet induces hypertension (HTN) in normal rats compared with a low-fat, complex-carbohydrate (LFCC) diet. Limited evidence suggests that high-fat or high-sugar diets cause enhanced generation of reactive oxygen species (ROS). We therefore hypothesized that by inducing oxidative stress, the HFS diet may promote nitric oxide (NO) inactivation and HTN. To test this hypothesis, female Fischer rats… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells

  • JS Pollock, U Forstermann, +4 authors F. Murad
  • Proc Natl Acad Sci U S A
  • 2000

Similar Papers

Loading similar papers…