Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics.

@article{Kim2015EnhancedMA,
  title={Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics.},
  author={Jong Hyun Kim and Yu Jin Jang and Su Yeon An and Jeongsang Son and Jaehun Lee and Gyunggyu Lee and Ji Young Park and Han-Jin Park and D Hwang and Jonghoon Kim and Jiyou Han},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2015},
  volume={147 1},
  pages={190-206}
}
Highly homogeneous and functional stem cell-derived hepatocyte-like cells (HLCs) are considered a promising option in the cell-based therapy of liver disease and the development of effective in vitro toxicity screening tools. However, the purity of cells and expression and/or activity of drug metabolizing enzymes in stem cell-derived HLCs are usually too low to be useful for clinical or in vitro applications. Here, we describe a highly optimized hepatic differentiation protocol, which produces… CONTINUE READING

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