Enhanced Membrane Pore Formation through High-Affinity Targeted Antimicrobial Peptides

Abstract

Many cationic antimicrobial peptides (AMPs) target the unique lipid composition of the prokaryotic cell membrane. However, the micromolar activities common for these peptides are considered weak in comparison to nisin, which follows a targeted, pore-forming mode of action. Here we show that AMPs can be modified with a high-affinity targeting module, which… (More)
DOI: 10.1371/journal.pone.0039768

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