Enhanced MCP-1 expression during ischemia/reperfusion injury is mediated by oxidative stress and NF-kappaB.

@article{Sung2002EnhancedME,
  title={Enhanced MCP-1 expression during ischemia/reperfusion injury is mediated by oxidative stress and NF-kappaB.},
  author={Fion Lan Sung and Tong Y Zhu and Kathy K W Au-Yeung and Yaw Chris Siow and O Karmin},
  journal={Kidney international},
  year={2002},
  volume={62 4},
  pages={1160-70}
}
BACKGROUND Renal ischemia/reperfusion injury is a major cause of acute renal failure in both native kidneys and renal allografts. One important feature of such injury is monocyte/macrophage infiltration into the renal tissue. The infiltration of monocytes/macrophages can be induced by chemotactic factors produced by renal cells. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant protein for monocyte recruitment. The objective of the present study was to investigate… CONTINUE READING

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