Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import

@inproceedings{He2014EnhancedLB,
  title={Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import},
  author={Chong He and Scott K. Tsuchiyama and Quynh Thi Thuy Nguyen and Ekaterina N. Plyusnina and Samuel R. Terrill and Sarah Sahibzada and Bhumil Patel and Alena R. Faulkner and Mikhail V. Shaposhnikov and Ruilin Tian and Mitsuhiro Tsuchiya and Matt Kaeberlein and Alexey Alexandrovich Moskalev and Brian Kennedy and Michael Polymenis},
  booktitle={PLoS genetics},
  year={2014}
}
The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibuprofen increased the lifespan of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster, indicative of conserved eukaryotic longevity effects. Studies in yeast indicate that ibuprofen destabilizes the Tat2p permease and inhibits… CONTINUE READING
17 Citations
81 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 81 references

Similar Papers

Loading similar papers…