Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor

@article{Collinson2002EnhancedLA,
  title={Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the $\alpha$5 Subunit of the GABAAReceptor},
  author={N. Collinson and F. Kuenzi and W. Jarolimek and K. Maubach and Rosa Cothliff and C. Sur and Alison J. Smith and F. Otu and O. Howell and J. Atack and R. Mckernan and G. Seabrook and G. Dawson and P. Whiting and T. Rosahl},
  journal={The Journal of Neuroscience},
  year={2002},
  volume={22},
  pages={5572 - 5580}
}
The α5 subunit of the GABAA receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization and the function of α5-containing GABAA receptors has been explored by targeted disruption of the α5 gene in mice. The α5 −/− mice showed a significantly improved performance in a water maze model of spatial learning, whereas the performance in non-hippocampal-dependent learning and in anxiety tasks were unaltered in comparison with wild-type… Expand
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