Enhanced K(+)-channel-mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE(-/-) mice.

@article{Beleznai2011EnhancedKE,
  title={Enhanced K(+)-channel-mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE(-/-) mice.},
  author={Timea Z Beleznai and Hiromichi Takano and Claire Hamill and Polina L Yarova and Gillian Douglas and Keith M. Channon and Kim A Dora},
  journal={Cardiovascular research},
  year={2011},
  volume={92 2},
  pages={199-208}
}
AIMS Agonists that evoke smooth muscle cell hyperpolarization have the potential to stimulate both local and conducted dilation. We investigated whether the endothelium-dependent vasodilators acetylcholine (ACh) and SLIGRL stimulated conducted dilation and whether this was altered by deficiency in apolipoprotein E (ApoE(-/-)). METHODS AND RESULTS Isolated mesenteric arteries were cannulated, pressurized, and precontracted with phenylephrine. Agonists were either added to the bath to study… CONTINUE READING

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