Enhanced Innate Inflammation Induced by Anti-BTLA Antibody in Dual Insult Model of Hemorrhagic Shock/Sepsis.

@article{Cheng2016EnhancedII,
  title={Enhanced Innate Inflammation Induced by Anti-BTLA Antibody in Dual Insult Model of Hemorrhagic Shock/Sepsis.},
  author={Tingting Cheng and Jianwen Bai and Chun-Shiang Chung and Yaping Chen and Bethany M. Biron and Alfred Ayala},
  journal={Shock},
  year={2016},
  volume={45 1},
  pages={40-9}
}
Sepsis following hemorrhagic shock is a common clinical condition, in which innate immune system suffers from severe suppression. B and T lymphocyte attenuator (BTLA) is an immune-regulatory coinhibitory receptor expressed not only on adaptive, but also on innate immune cells. Our previous data showed that BTLA gene deficient mice were protected from septic mortality when compared with wild-type control C57BL/6 mice. Here, we extended our study by treating C57BL/6 mice with an anti-BTLA… CONTINUE READING