Enhanced Immune Response to DNA Vaccine Encoding Bacillus anthracis PA-D4 Protects Mice against Anthrax Spore Challenge

@inproceedings{Kim2015EnhancedIR,
  title={Enhanced Immune Response to DNA Vaccine Encoding Bacillus anthracis PA-D4 Protects Mice against Anthrax Spore Challenge},
  author={Na Young Kim and Dong Suk Chang and Yeonsu Kim and Chang H Kim and Gyeung Haeng Hur and Jai Myung Yang and Sungho Shin and Adam Driks},
  booktitle={PloS one},
  year={2015}
}
Anthrax has long been considered the most probable bioweapon-induced disease. The protective antigen (PA) of Bacillus anthracis plays a crucial role in the pathogenesis of anthrax. In the current study, we evaluated the efficiency of a genetic vaccination with the fourth domain (D4) of PA, which is responsible for initial binding of the anthrax toxin to the cellular receptor. The eukaryotic expression vector was designed with the immunoglobulin M (IgM) signal sequence encoding for PA-D4, which… CONTINUE READING

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