Enhanced GM1 ganglioside catabolism in cultured fibroblasts from Alzheimer patients.

@article{Pitto2005EnhancedGG,
  title={Enhanced GM1 ganglioside catabolism in cultured fibroblasts from Alzheimer patients.},
  author={Marina Pitto and Francesca Raimondo and Chiara Paola Zoia and Laura Brighina and Carlo Ferrarese and Massimo Masserini},
  journal={Neurobiology of aging},
  year={2005},
  volume={26 6},
  pages={833-8}
}
The metabolic processing of GM1 ganglioside, exogenously administered to cultured skin fibroblasts, was investigated on cells obtained from patients affected with Alzheimer disease, in comparison with age-matched control subjects. Cultured fibroblasts were incubated with GM1 ganglioside, [(3)H]-radiolabelled at the sphingosine moiety. It was observed that the extent of tritiated GM2 and GM3 ganglioside formation was higher in AD fibroblasts than in control cells. The activity of acidic beta-D… CONTINUE READING
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