Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays

@article{Rangel2018EnhancedEV,
  title={Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays},
  author={Gabriel W Rangel and M. Clark and Usheer Kanjee and C. Lim and Kathryn Shaw-Saliba and M. J. Menezes and Anjali Mascarenhas and L. Chery and E. Gomes and P. Rathod and Marcelo U. Ferreira and M. Duraisingh},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2018},
  volume={62}
}
ABSTRACT Plasmodium vivax chloroquine resistance has been documented in nearly every region where this malaria-causing parasite is endemic. Unfortunately, P. vivax resistance surveillance and drug discovery are challenging due to the low parasitemias of patient isolates and poor parasite survival through ex vivo maturation that reduce the sensitivity and scalability of current P. vivax antimalarial assays. Using cryopreserved patient isolates from Brazil and fresh patient isolates from India… Expand
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