Enhanced Evolvability in Immunoglobulin V Genes Under Somatic Hypermutation

@article{Cowell1999EnhancedEI,
  title={Enhanced Evolvability in Immunoglobulin V Genes Under Somatic Hypermutation},
  author={Lindsay G. Cowell and Hye-Jung Kim and Tiina Humaljoki and Claudia Berek and Thomas B. Kepler},
  journal={Journal of Molecular Evolution},
  year={1999},
  volume={49},
  pages={23-26}
}
Darwinian theory requires that mutations be produced in a nonanticipatory manner; it is nonetheless consistent to suggest that mutations that have repeatedly led to nonviable phenotypes would be introduced less frequently than others—if under appropriate genetic control. Immunoglobulins produced during infection acquire point mutations that are subsequently selected for improved binding to the eliciting antigen. We and others have speculated that an enhancement of mutability in the… CONTINUE READING
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