Enhanced Drug-Induced Apoptosis Associated with P-Glycoprotein Overexpression Is Specific to Antimicrotubule Agents

@article{Li2003EnhancedDA,
  title={Enhanced Drug-Induced Apoptosis Associated with P-Glycoprotein Overexpression Is Specific to Antimicrotubule Agents},
  author={Dong Li and Seong Hoon Jang and Jonghan Kim and M. Guillaume Wientjes and Jessie L.-S. Au},
  journal={Pharmaceutical Research},
  year={2003},
  volume={20},
  pages={45-50}
}
AbstractPurpose. We have reported that overexpression of mdr1 P-glycoprotein (Pgp) is associated with a higher sensitivity to paclitaxel-induced apoptosis (1,2). The present study examined the substrate specificity of this phenomenon. Methods. Two Pgp substrates (vincristine and doxorubicin) and three nonsubstrates (cisplatin, camptothecin, and 5-fluorouracil) were studied. Serum deprivation, known to induce apoptosis, was used as a comparison. Results. The Pgp nonsubstrates and serum… CONTINUE READING

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