Enhanced Cdk5 Activity and p35 Translocation in the Ventral Striatum of Acute and Chronic Methamphetamine-Treated Rats

@article{Chen2005EnhancedCA,
  title={Enhanced Cdk5 Activity and p35 Translocation in the Ventral Striatum of Acute and Chronic Methamphetamine-Treated Rats},
  author={Pei-Chun Chen and J C Chen},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={538-549}
}
The cyclin-dependent kinase Cdk5 and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of Mr 32 kDa)-dependent signaling have been implicated in the regulation of dopaminergic neurotransmission after chronic cocaine treatment. In this study, we examined if Cdk5 signaling participates in the behavioral and biochemical effect of acute and chronic methamphetamine (METH) treatment. We found that Cdk5 activity and the membrane fraction of p35 protein, a Cdk5 activator, in the ventral striatum… CONTINUE READING

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