Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice.

Abstract

We have found that DR6, a member of the TNF receptor family, is highly expressed in resting T cells and downregulated in activated T cells. DR6-targeted mutant mice were generated and showed normal development. However, DR6(-/-) CD4(+) T cells hyperproliferated in response to TCR-mediated stimulation and protein antigen challenge. Activated DR6(-/-) CD4… (More)

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Cite this paper

@article{Liu2001EnhancedCT, title={Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice.}, author={Jin Hua Liu and Se - Young Na and A W Glasebrook and Niles Fox and Patricia J. Solenberg and Q Zhang and Ho Young Song and Dongshan Yang}, journal={Immunity}, year={2001}, volume={15 1}, pages={23-34} }