Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections.

@article{Oliviero2011EnhancedBD,
  title={Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections.},
  author={Barbara Oliviero and Antonella Cerino and Stefania Varchetta and Enrica Paudice and Somnath Pai and Serena Ludovisi and Marco Zaramella and Giuseppe Michelone and Paolo Pugnale and F. de Toro Negro and Vincenzo Barnaba and Mario U. Mondelli},
  journal={Journal of hepatology},
  year={2011},
  volume={55 1},
  pages={53-60}
}
BACKGROUND & AIMS Chronic microbial infections are frequently associated with B-cell activation and polyclonal proliferation, potentially leading to autoimmunity and lymphoproliferative disorders. We assessed B-cell phenotype and function in chronic hepatitis B (HBV) and chronic hepatitis C (HCV) virus infection. METHODS We studied 70 patients with chronic HCV infection, 34 with chronic HBV infection and 54 healthy controls. B-cell phenotype was assessed by flow cytometry using monoclonal… CONTINUE READING

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