Enhanced Autophagy in Polycystic Kidneys of AQP11 Null Mice

@inproceedings{Tanaka2016EnhancedAI,
  title={Enhanced Autophagy in Polycystic Kidneys of AQP11 Null Mice},
  author={Yasuko Tanaka and Mayumi Watari and Tatsuya Saito and Yoshiyuki Morishita and Kenichi Ishibashi},
  booktitle={International journal of molecular sciences},
  year={2016}
}
Aquaporin-11 (AQP11) is an intracellular water channel expressed at the endoplasmic reticulum (ER) of the proximal tubule. Its gene disruption in mice leads to intracellular vacuole formation at one week and the subsequent development of polycystic kidneys by three weeks. As the damaged proximal tubular cells with intracellular vacuoles form cysts later, we… CONTINUE READING