Enhanced Antitumor Effect of 5′‐Deoxy‐5‐fluorouridine by Oral Administration with l‐Cysteine

@article{Iigo1989EnhancedAE,
  title={Enhanced Antitumor Effect of 5′‐Deoxy‐5‐fluorouridine by Oral Administration with l‐Cysteine},
  author={Masaaki Iigo and Yoko Nakajima and Eiji Araki and Akio Hoshi},
  journal={Japanese Journal of Cancer Research : Gann},
  year={1989},
  volume={80},
  pages={182 - 187}
}
  • Masaaki Iigo, Yoko Nakajima, +1 author Akio Hoshi
  • Published 1989
  • Biology, Medicine
  • Japanese Journal of Cancer Research : Gann
  • When given orally in combination with l‐cysteine, 5′‐deoxy‐5‐fluorouridine (DFUR) brought about a significant reduction in the growth of adenocarcinoma 755 and a significant prolongation of life‐span in mice bearing Lewis lung carcinoma without increased toxicity to the host as compared with DFUR alone, though l‐cysteine alone did not show an appreciable antitnmor activity. Moreover, the combination of DFUR and l‐cysteine resulted in a marked retardation of growth of human colon tumor LS174T… CONTINUE READING