Enhanced 17 alpha-hydroxylation of pregnenolone and increased androgen production by rabbit adrenocortical cells stimulated chronically with corticotropin.

@article{Kolanowski1986Enhanced1A,
  title={Enhanced 17 alpha-hydroxylation of pregnenolone and increased androgen production by rabbit adrenocortical cells stimulated chronically with corticotropin.},
  author={J. Kolanowski and N. Ort{\'e}ga and J. Crabb{\'e}},
  journal={Journal of steroid biochemistry},
  year={1986},
  volume={24 1},
  pages={
          335-9
        }
}
  • J. Kolanowski, N. Ortéga, J. Crabbé
  • Published 1986
  • Chemistry, Biology, Medicine
  • Journal of steroid biochemistry
  • The postulated chronic stimulatory effect of corticotropin (ACTH) on pregnenolone production and on 17 alpha-hydroxylase activity was evaluated on adrenocortical cells obtained from control and chronically ACTH-treated rabbits. The cells were incubated with various concentrations of ACTH added alone or together with trilostane, so as to inhibit further conversion of pregnenolone and dehydroepiandrosterone. The maximal steroidogenic effect of ACTH (determined in the absence of trilostane) was… CONTINUE READING
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    References

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