Enhanced 17 alpha-hydroxylation of pregnenolone and increased androgen production by rabbit adrenocortical cells stimulated chronically with corticotropin.

@article{Kolanowski1986Enhanced1A,
  title={Enhanced 17 alpha-hydroxylation of pregnenolone and increased androgen production by rabbit adrenocortical cells stimulated chronically with corticotropin.},
  author={J. Kolanowski and N. Ort{\'e}ga and J. Crabb{\'e}},
  journal={Journal of steroid biochemistry},
  year={1986},
  volume={24 1},
  pages={
          335-9
        }
}
  • J. Kolanowski, N. Ortéga, J. Crabbé
  • Published 1986
  • Chemistry, Biology, Medicine
  • Journal of steroid biochemistry
    • The postulated chronic stimulatory effect of corticotropin (ACTH) on pregnenolone production and on 17 alpha-hydroxylase activity was evaluated on adrenocortical cells obtained from control and chronically ACTH-treated rabbits. The cells were incubated with various concentrations of ACTH added alone or together with trilostane, so as to inhibit further conversion of pregnenolone and dehydroepiandrosterone. The maximal steroidogenic effect of ACTH (determined in the absence of trilostane) was… CONTINUE READING
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    Citation Type

    Corticotropin-induced changes in enzymatic activities of the post-pregnenolone steroidogenic pathway in rabbit adrenocortical cells.
    • 3
    Chronic treatment with corticotropin increases the capacity of rabbit adrenocortical cells to convert pregnenolone into androgens.
    • 6
    Effect of ACTH on steroidogenic enzymes in guinea pig fasciculata-glomerulosa cells: Changes in activity and mRNA levels
    • 20
    Effect of chronic ACTH treatment on guinea-pig adrenal steroidogenesis: Steroid plasma levels, steroid adrenal levels, activity of steroidogenic enzymes and their steady-state mRNA levels
    • 21
    Urinary excretion of free progestins, androgens, and estradiol after injection of (1-24)ACTH in the Mongolian gerbil.
    • 1

    References

    SHOWING 1-10 OF 25 REFERENCES
    The prolonged stimulatory effect of ACTH on 11 beta-hydroxylation, and its contribution to the steroidogenic potency of adrenocortical cells.
    • 9
    The enhancement of pregnenolone production as the main mechanism of the prolonged stimulatory effect of ACTH on cortisol production by guinea-pig adrenocortical cells.
    • 6
    The stimulatory effect of corticotropin on cortisol biosynthetic pathway in guinea-pig adrenocortical cells.
    • 8
    The stimulation by ACTH of 17α-hydroxylation in cultures or rabbit adrenal cells
    • 5
    Factors affecting the adrenocorticotropic hormone stimulation of rabbit adrenal 17alpha-hydroxylase activity.
    • 32
    The mechanism of action of adrenocroticotropic hormone. The role of mitochondrial cholesterol accumulation in the regulation of steroidogenesis.
    • 115
    Changes in corticosteroid secretory pattern induced by prolonged corticotropin treatment in the rabbit.
    • 16
    Characteristics of the response of human adrenocortical cells to ACTH
    • 24
    Modification of rabbit adrenal steroid biosynthesis by prolonged ACTH administration.
    • 22
    • PDF
    On the mechanism of action of the adrenocorticotrophic hormone. The stimulation of the activity of enzymes involved in pregnenolone synthesis.
    • 122