Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation.

@article{Das2014EngulfmentOA,
  title={Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation.},
  author={Amitava Das and Kasturi Ganesh and Savita Khanna and Chandan K. Sen and Sashwati Roy},
  journal={Journal of immunology},
  year={2014},
  volume={192 3},
  pages={1120-9}
}
At an injury site, efficient clearance of apoptotic cells by wound macrophages or efferocytosis is a prerequisite for the timely resolution of inflammation. Emerging evidence indicates that microRNA-21 (miR-21) may regulate the inflammatory response. In this work, we sought to elucidate the significance of miR-21 in the regulation of efferocytosis-mediated suppression of innate immune response, a key process implicated in resolving inflammation following injury. An increased expression of… CONTINUE READING
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