Engraftment of human central memory-derived effector CD8+ T cells in immunodeficient mice.

@article{Wang2011EngraftmentOH,
  title={Engraftment of human central memory-derived effector CD8+ T cells in immunodeficient mice.},
  author={Xiuli Wang and Carolina Berger and Chinglam W Wong and Stephen J. Forman and Stanley R Riddell and Michael C. Jensen},
  journal={Blood},
  year={2011},
  volume={117 6},
  pages={1888-98}
}
In clinical trials of adoptive T-cell therapy, the persistence of transferred cells correlates with therapeutic efficacy. However, properties of human T cells that enable their persistence in vivo are poorly understood, and model systems that enable investigation of the fate of human effector T cells (T(E)) have not been described. Here, we analyzed the engraftment of adoptively transferred human cytomegalovirus pp65-specific CD8(+) T(E) cells derived from purified CD45RO(+)CD62L(+) central… CONTINUE READING