Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy.

@article{Giralt1997EngraftmentOA,
  title={Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy.},
  author={Sergio A Giralt and Elihu Estey and Maher Albitar and Koen M. van Besien and Gabriela Rond{\'o}n and Paolo N Anderlini and Susan O'brien and Issa F. Khouri and James Gajewski and Rakesh Mehra and David F. Claxton and Borje S. Andersson and Miloslav E Beran and Donna Przepiorka and Charles Koller and Steven M. Kornblau and Martin K\orbling and Michael Keating and Hagop A Kantarjian and Richard E. Champlin},
  journal={Blood},
  year={1997},
  volume={89 12},
  pages={4531-6}
}
The immune-mediated graft-versus-leukemia effect is important to prevent relapse after allogeneic progenitor cell transplantation. This process requires engraftment of donor immuno-competent cells. The objective of this study was to assess the feasibility of achieving engraftment of allogeneic peripheral blood or bone marrow progenitor cell after purine analog containing nonmyeloablative chemotherapy. Patients with advanced leukemia or myelodysplastic syndromes (MDS) who were not candidates for… CONTINUE READING
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