Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice.

@article{Hogan1997EngraftmentAD,
  title={Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice.},
  author={Christopher J. Hogan and Elizabeth J Shpall and Orla M McNulty and IK McNiece and John E Dick and Leonard D Shultz and Gordon Keller},
  journal={Blood},
  year={1997},
  volume={90 1},
  pages={85-96}
}
Understanding the repopulating characteristics of human hematopoietic stem/progenitor cell fractions is crucial for predicting their performance after transplant into high-risk patients following high-dose therapy. We report that human umbilical cord blood cells, 78% to 100% of which express the hematopoietic progenitor cell surface marker CD34, can consistently engraft, develop, and proliferate in the hematopoietic tissues of sublethally irradiated NOD/LtSz-scid/scid mice. Engraftment and… CONTINUE READING

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