Engineering vaccines with heterologous B and T cell epitopes using immunoglobulin genes

Abstract

Antibodies engineered in their variable domain to express epitopes of heterologous antigens—antigenized antibodies—function as immunogens. Only the third complementarity-determining region (CDR3) of the H chain has been used as the site of epitope expression, as this loop has the highest natural variability in length and amino acid composition. We… (More)
DOI: 10.1038/nbt0997-882

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