Engineering tumor-targeted gadolinium hexanedione nanoparticles for potential application in neutron capture therapy.

  title={Engineering tumor-targeted gadolinium hexanedione nanoparticles for potential application in neutron capture therapy.},
  author={Moses O. Oyewumi and Russell J. Mumper},
  journal={Bioconjugate chemistry},
  volume={13 6},
Microemulsions (oil-in-water) have been employed as templates to engineer nanoparticles containing high concentrations of gadolinium for potential application in neutron capture therapy of tumors. Gadolinium hexanedione (GdH), synthesized by complexation of Gd(3+) with 2,4-hexanedione, was used as the nanoparticle matrix alone or in combination with either emulsifying wax or PEG-400 monostearate. Solid nanoparticles (<125 nm size) were obtained by simple cooling of the microemulsions prepared… 
Gadolinium incorporated reconstituted chylomicron emulsion for potential application in tumor neutron capture therapy.
  • Annie M Dierling, Brian R. Sloat, Z. Cui
  • Biology
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2006
Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice.
Preparation and characterization of MRI-active gadolinium nanocomposite particles for neutron capture therapy
In vitro cytotoxicity was investigated with three kinds of normal and cancer cells, and in vitro and in vivo MRI analyses were performed to confirm the contrast ability, accumulation, and sustentation of NPs in tumor tissues.
Gd@C82 metallofullerenes for neutron capture therapy—fullerene solubilization by poly(ethylene glycol)-block-poly(2-(N, N-diethylamino)ethyl methacrylate) and resultant efficacy in vitro
Neutron irradiation of cultured cells with Gd@C82-PEG-b-PAMA-complexed nanoparticles showed effective cytotoxicity, indicating the effective emission of gamma rays and internal conversion electrons produced from the neutron capture reaction of Gd.
Tumor imaging using P866, a high‐relaxivity gadolinium chelate designed for folate receptor targeting
While this high‐relaxivity folate‐Gd chelate has demonstrated its potential capacity to target in vivo FR on tumors, the sensitivity is probably limited to a certain extent by the saturation of the FR and by the decrease in the apparent relaxivity of the internalized part of P866 in the tumor cells.
Magnetic resonance imaging, gadolinium neutron capture therapy, and tumor cell detection using ultrasmall Gd2O3 nanoparticles coated with polyacrylic acid-rhodamine B as a multifunctional tumor theragnostic agent
Results demonstrate that ultrasmall Gd2O3 nanoparticle colloids are the potential multifunctional tumor theragnostic agent and exhibit stronger fluorescent intensities in tumor cells than in normal cells owing to conjugated Rho, proving their pH-sensitive fluorescent tumor cell detection ability.
Folic acid mediated synaphic delivery of doxorubicin using biogenic gold nanoparticles anchored to biological linkers.
The GNPs-FA-DOX complex was found be non-toxic for normal cells and considerably toxic for HeLa cells, and doxorubicin release kinetics using GNPs followed 1st order at pH 5.3 which is ideal for solid tumor targeting.