Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm.

@article{Ye2000EngineeringTP,
  title={Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm.},
  author={Xudong Ye and Salim Al‐Babili and Andreas Klöti and J Zhang and Paola Lucca and Peter Beyer and Ingo Potrykus},
  journal={Science},
  year={2000},
  volume={287 5451},
  pages={
          303-5
        }
}
Rice (Oryza sativa), a major staple food, is usually milled to remove the oil-rich aleurone layer that turns rancid upon storage, especially in tropical areas. The remaining edible part of rice grains, the endosperm, lacks several essential nutrients, such as provitamin A. Thus, predominant rice consumption promotes vitamin A deficiency, a serious public health problem in at least 26 countries, including highly populated areas of Asia, Africa, and Latin America. Recombinant DNA technology was… 

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