Engineering the heterologous expression of lanthipeptides in Escherichia coli by multigene assembly

@article{Kuthning2015EngineeringTH,
  title={Engineering the heterologous expression of lanthipeptides in Escherichia coli by multigene assembly},
  author={Anja Kuthning and Eva M{\"o}sker and Roderich D S{\"u}ssmuth},
  journal={Applied Microbiology and Biotechnology},
  year={2015},
  volume={99},
  pages={6351-6361}
}
Lantibiotics are an important class of ribosomally synthesised peptide antibiotics with a remarkable pharmacological potential. Structural variants of lantibiotics generated by peptide engineering in vivo are an important aspect for improving the peptide’s efficacy, stability and bioavailability as well as production titre, which severely impacts the potential exploitation in pharmaceutical applications. Therefore, expression systems are needed which allow for a robust genetic access for ample… CONTINUE READING
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