Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception

@article{Shrestha2021EngineeringSI,
  title={Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception},
  author={Bhawana Shrestha and Alison Schaefer and Yong Zhu and Jamal Saada and Timothy M. Jacobs and Elizabeth C. Chavez and Stuart S. Omsted and Carlos A Cruz-Teran and Gabriela Baldeon Vaca and Kathleen Listiak Vincent and Thomas R. Moench and Samuel K. Lai},
  journal={Science Translational Medicine},
  year={2021},
  volume={13}
}
A panel of anti-sperm IgGs that effectively agglutinate human sperm in vitro and in sheep has been developed for nonhormonal contraception. Stopping sperm in its tracks Many women have contraindications to or are dissatisfied with hormone-based birth control. Here, Shrestha and colleagues developed a panel of sperm-binding antibodies based on an immunoglobulin against human sperm isolated from an infertile woman. By engineering the antibodies to contain additional antigen-binding fragments… 

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