Engineering-specific pharmacological binding sites for peptidyl inhibitors of potassium channels into KcsA.

@article{Legros2002EngineeringspecificPB,
  title={Engineering-specific pharmacological binding sites for peptidyl inhibitors of potassium channels into KcsA.},
  author={Christian Legros and Christian Schulze and M. L. Garcia and Pierre Edouard Bougis and Marie-France Martin-Eauclaire and Olaf Pongs},
  journal={Biochemistry},
  year={2002},
  volume={41 51},
  pages={15369-75}
}
The bacterial potassium channel, KcsA, can be modified to express a high-affinity receptor site for the scorpion toxin kaliotoxin (KTX) by substituting subregion I in the P region of KcsA with the one present in the human voltage-gated potassium channel Kv1.3 [Legros, C., Pollmann, V., Knaus, H. G., Farrell, A. M., Darbon, H., Bougis, P. E., Martin-Eauclaire, M. F., and Pongs, O. (2000) J. Biol. Chem. 275, 16918-16924]. This approach opened the way to investigate whether sequence differences in… CONTINUE READING
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