Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation.

@article{Pedrotty2005EngineeringSM,
  title={Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation.},
  author={Dawn Marie Theresa Pedrotty and Jennifer Koh and Bryce H. Davis and Doris A Taylor and Patrick Wolf and Laura E. Niklason},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 4},
  pages={H1620-6}
}
Immature skeletal muscle cells, or myoblasts, have been used in cellular cardiomyoplasty in attempts to regenerate cardiac muscle tissue by injection of cells into damaged myocardium. In some studies, muscle tissue within myoblast implant sites may be morphologically similar to cardiac muscle. We hypothesized that identifiable aspects of the cardiac milieu may contribute to growth and development of implanted myoblasts in vivo. To test this hypothesis, we designed a novel in vitro system to… CONTINUE READING

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