Engineering redox cofactor regeneration for improved pentose fermentation in Saccharomyces cerevisiae.

@article{Verho2003EngineeringRC,
  title={Engineering redox cofactor regeneration for improved pentose fermentation in Saccharomyces cerevisiae.},
  author={Ritva Verho and John Londesborough and Merja Penttil{\"a} and Peter Richard},
  journal={Applied and environmental microbiology},
  year={2003},
  volume={69 10},
  pages={
          5892-7
        }
}
Pentose fermentation to ethanol with recombinant Saccharomyces cerevisiae is slow and has a low yield. A likely reason for this is that the catabolism of the pentoses D-xylose and L-arabinose through the corresponding fungal pathways creates an imbalance of redox cofactors. The process, although redox neutral, requires NADPH and NAD+, which have to be regenerated in separate processes. NADPH is normally generated through the oxidative part of the pentose phosphate pathway by the action of… CONTINUE READING

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