Engineering processive DNA polymerases with maximum benefit at minimum cost

Abstract

DNA polymerases need to be engineered to achieve optimal performance for biotechnological applications, which often require high fidelity replication when using modified nucleotides and when replicating difficult DNA sequences. These tasks are achieved for the bacteriophage T4 DNA polymerase by replacing leucine with methionine in the highly conserved Motif… (More)
DOI: 10.3389/fmicb.2014.00380

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Cite this paper

@inproceedings{RehaKrantz2014EngineeringPD, title={Engineering processive DNA polymerases with maximum benefit at minimum cost}, author={Linda Reha-Krantz and Sandra Woodgate and Myron F. Goodman}, booktitle={Front. Microbiol.}, year={2014} }