Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds.

@article{Chan2011EngineeringPP,
  title={Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds.},
  author={Lai Yue Chan and Sunithi Gunasekera and S{\'o}nia Troeira Henriques and Nathalie F Worth and Sarah-Jane Le and Richard J Clark and Julie H. Campbell and David J. Craik and Norelle L Daly},
  journal={Blood},
  year={2011},
  volume={118 25},
  pages={6709-17}
}
Fragments from the extracellular matrix proteins laminin and osteopontin and a sequence from VEGF have potent proangiogenic activity despite their small size (< 10 residues). However, these linear peptides have limited potential as drug candidates for therapeutic angiogenesis because of their poor stability. In the present study, we show that the therapeutic potential of these peptides can be significantly improved by "grafting" them into cyclic peptide scaffolds. Momordica cochinchinensis… CONTINUE READING
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