Engineering poly(ethylene oxide) buccal films with cyclodextrin: a novel role for an old excipient?

@article{Miro2013EngineeringPO,
  title={Engineering poly(ethylene oxide) buccal films with cyclodextrin: a novel role for an old excipient?},
  author={Agnese Miro and Ivana d'Angelo and Antonella Nappi and Pietro La Manna and Marco Biondi and Laura Mayol and Pellegrino Musto and Roberto Russo and Maria Immacolata La Rotonda and Francesca Ungaro and Fabiana Quaglia},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={452 1-2},
  pages={283-91}
}
Inspired by the multiple roles cyclodextrins can play in polymeric systems, here we engineered poly(ethylene oxide) (PEO) films with (2-hydroxypropyl)-β-cyclodextrin (CD) as multipurpose ingredient. To shed light on the potential of CD in formulating PEO buccal films for the delivery of poorly water-soluble drugs, we preliminarily assessed thermal and mechanical properties as well as wettability of films prepared at different PEO/CD ratios. PEO/CD platform containing 54% by weight of CD was… CONTINUE READING

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