Engineering of ubiquinone biosynthesis using the yeast coq2 gene confers oxidative stress tolerance in transgenic tobacco.

@article{Ohara2004EngineeringOU,
  title={Engineering of ubiquinone biosynthesis using the yeast coq2 gene confers oxidative stress tolerance in transgenic tobacco.},
  author={Kazuaki Ohara and Yoshimasa Kokado and Hirobumi Yamamoto and Fumihiko Sato and Kazufumi Yazaki},
  journal={The Plant journal : for cell and molecular biology},
  year={2004},
  volume={40 5},
  pages={734-43}
}
Ubiquinone (UQ), an electron carrier in the respiratory chain ranging from bacteria to humans, shows antioxidative activity in vitro, but its physiological role in vivo is not yet clarified in plants. UQ biosynthesis was modified by overexpressing the yeast gene coq2, which encodes p-hydroxybenzoate:polyprenyltransferase, to increase the accumulation of UQ-6 in yeast and UQ-10 in tobacco. The yeast and tobacco transgenic lines showed about a three- and six-fold increase in UQ, respectively… CONTINUE READING