Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study.

@article{Pei2008EngineeringOF,
  title={Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study.},
  author={Ming Pei and F. F. He and Vincent L. Kish and Gordana Vunjak-Novakovic},
  journal={Clinical orthopaedics and related research},
  year={2008},
  volume={466 8},
  pages={1880-9}
}
Stem cells derived from synovial lining-synovial lining--derived stem cells or SDSCs--are a promising cell source for cartilage tissue engineering. We hypothesized that negatively selected SDSCs would form cartilage constructs and conventionally passaged SDSCs would be contaminated with macrophages, inhibiting SDSC-based chondrogenesis. We mixed SDSCs with fibrin gel and seeded the cells into polyglycolic acid scaffolds. After 3 days of incubation with a proliferative growth factor cocktail… CONTINUE READING
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