Engineering of an l-arabinose metabolic pathway in Corynebacterium glutamicum

@article{Kawaguchi2007EngineeringOA,
  title={Engineering of an l-arabinose metabolic pathway in Corynebacterium glutamicum},
  author={Hideo Kawaguchi and Miho Sasaki and Alain A. Vert{\`e}s and Masayuki Inui and Hideaki Yukawa},
  journal={Applied Microbiology and Biotechnology},
  year={2007},
  volume={77},
  pages={1053-1062}
}
Corynebacterium glutamicum was metabolically engineered to broaden its substrate utilization range to include the pentose sugar l-arabinose, a product of the degradation of lignocellulosic biomass. The resultant CRA1 recombinant strain expressed the Escherichia coli genes araA, araB, and araD encoding l-arabinose isomerase, l-ribulokinase, and l-ribulose-5-phosphate 4-epimerase, respectively, under the control of a constitutive promoter. Unlike the wild-type strain, CRA1 was able to grow on… CONTINUE READING

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