Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules.

  title={Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules.},
  author={Eun-Mi Hur and In Hong Yang and Deok-Ho Kim and Justin Byun and Saijilafu and Wen-Lin Xu and Philip R Nicovich and Raymond Cheong and Andre Levchenko and Nitish V. Thakor and Feng-quan Zhou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 12},
Neurons in the central nervous system (CNS) fail to regenerate axons after injuries due to the diminished intrinsic axon growth capacity of mature neurons and the hostile extrinsic environment composed of a milieu of inhibitory factors. Recent studies revealed that targeting a particular group of extracellular inhibitory factors is insufficient to trigger long-distance axon regeneration. Instead of antagonizing the growing list of impediments, tackling a common target that mediates axon growth… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 43 references

Compartmentalized micro fl uidic culture platform to study mechanism of paclitaxelinduced axonal degeneration

S Neumann, CJ Woolf
Exp Neurol • 2009

PTP{sigma} is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration

Y Shen
Science • 2009

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