Engineering microscale cellular niches for three-dimensional multicellular co-cultures.

@article{Huang2009EngineeringMC,
  title={Engineering microscale cellular niches for three-dimensional multicellular co-cultures.},
  author={Carlos Huang and Jente Lu and Hyeryung Seon and A. Lee and L. Flanagan and H. Kim and A. J. Putnam and N. L. Jeon},
  journal={Lab on a chip},
  year={2009},
  volume={9 12},
  pages={
          1740-8
        }
}
Modeling the in vivo microenvironment typically involves placing cells in a three-dimensional (3D) extracellular matrix (ECM) in physiologically relevant context with respect to other cells. The mechanical and chemical features of 3D microenvironments play important roles in tissue engineering, tumor growth and metastasis, and in defining stem cell niches, and it is increasingly recognized that cells behave much differently when surrounded by a 3D ECM than when anchored to a 2D substrate. To… Expand
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