Engineering interpenetrating network hydrogels as biomimetic cell niche with independently tunable biochemical and mechanical properties.

@article{Tong2014EngineeringIN,
  title={Engineering interpenetrating network hydrogels as biomimetic cell niche with independently tunable biochemical and mechanical properties.},
  author={Xinming Tong and Fan Yang},
  journal={Biomaterials},
  year={2014},
  volume={35 6},
  pages={
          1807-15
        }
}
Hydrogels have been widely used as artificial cell niche to mimic extracellular matrix with tunable properties. However, changing biochemical cues in hydrogels developed-to-date would often induce simultaneous changes in mechanical properties, which do not support mechanistic studies on stem cell-niche interactions. Here we report the development of a PEG-based interpenetrating network (IPN), which is composed of two polymer networks that can independently and simultaneously crosslink to form… CONTINUE READING
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