Engineering human neo-tendon tissue in vitro with human dermal fibroblasts under static mechanical strain.

@article{Deng2009EngineeringHN,
  title={Engineering human neo-tendon tissue in vitro with human dermal fibroblasts under static mechanical strain.},
  author={Dan Deng and Wei Liu and Feng Xu and Yang Yang and Guangdong Zhou and Wen Zhang and Lei Cui and Y. Uny Cao},
  journal={Biomaterials},
  year={2009},
  volume={30 35},
  pages={6724-30}
}
Proper cell source is one of the key issues for tendon engineering. Our previous study showed that dermal fibroblasts could be used to successfully engineer tendon in vivo and tenocytes could engineer neo-tendon in vitro with static strain. This study further investigated the possibility of engineering human neo-tendon tissue in vitro using dermal fibroblasts. Human dermal fibroblasts were seeded on polyglycolic acid (PGA) fibers pre-fixed on a U-shape as a mechanical loading group, or simply… CONTINUE READING