Engineering clustered ligand binding into nonviral vectors: alphavbeta3 targeting as an example.

@article{Ng2009EngineeringCL,
  title={Engineering clustered ligand binding into nonviral vectors: alphavbeta3 targeting as an example.},
  author={Quinn K T Ng and Marie K Sutton and Pan Soonsawad and Li Xing and Holland R Cheng and Tatiana Segura},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2009},
  volume={17 5},
  pages={
          828-36
        }
}
The development of techniques to efficiently deliver genes using nonviral approaches can broaden the application of gene delivery in medical applications without the safety concerns associated with viral vectors. Here, we designed a clustered integrin-binding platform to enhance the efficiency and targetability of nonviral gene transfer to HeLa cells with low and high densities of alpha(v)beta(3) integrin receptors. Arg-Gly-Asp (RGD) nanoclusters were formed using gold nanoparticles… CONTINUE READING

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