Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)

  title={Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)},
  author={Yann H{\'e}rault and Minoo Rassoulzadegan and François Cuzin and Denis Duboule.},
  journal={Nature Genetics},
Functional studies of large transcription units, clustered genes and chromosomal loci require the design of novel experimental tools to engineer genomic macro-rearrangements. Here, we present a strategy to produce deficiencies or duplications by crossing mice carrying loxP sites in homologous loci. This trans-allelic targeted meiotic recombination (TAMERE) protocol allows for the combination of various alleles within a particular locus as well as for generation of interchromosomal unequal… CONTINUE READING


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