Engineering cell shape and function.

@article{Singhvi1994EngineeringCS,
  title={Engineering cell shape and function.},
  author={Ritu Singhvi and Awadhesh Kumar and Gabriel P L{\'o}pez and Gregory Stephanopoulos and Daniel I. C. Wang and George M Whitesides and Donald E. Ingber},
  journal={Science},
  year={1994},
  volume={264 5159},
  pages={696-8}
}
An elastomeric stamp, containing defined features on the micrometer scale, was used to imprint gold surfaces with specific patterns of self-assembled monolayers of alkanethiols and, thereby, to create islands of defined shape and size that support extracellular matrix protein adsorption and cell attachment. Through this technique, it was possible to place cells in predetermined locations and arrays, separated by defined distances, and to dictate their shape. Limiting the degree of cell… CONTINUE READING
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