Engineering botulinum neurotoxin to extend therapeutic intervention.

  title={Engineering botulinum neurotoxin to extend therapeutic intervention.},
  author={Sheng Chen and Joseph T. Barbieri},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 23},
Clostridium botulinum neurotoxins (BoNTs) are effective therapeutics for a variety of neurological disorders, such as strabismus, blepharospam, hemificial spasm, and cervical dystonia, because of the toxin's tropism for neurons and specific cleavage of neuronal soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNARE) proteins. Modifying BoNT to bind nonneuronal cells has been attempted to extend therapeutic applications. However, prerequisite to develop nonneuronal… CONTINUE READING
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