Engineering biotin prototrophic Corynebacterium glutamicum strains for amino acid, diamine and carotenoid production.

@article{PetersWendisch2014EngineeringBP,
  title={Engineering biotin prototrophic Corynebacterium glutamicum strains for amino acid, diamine and carotenoid production.},
  author={Petra Peters-Wendisch and Susanne G{\"o}tker and Sabine A. E. Heider and Gajendar Komati Reddy and Anh Quoc Nguyen and Kathrin C Stansen and Volker F Wendisch},
  journal={Journal of biotechnology},
  year={2014},
  volume={192 Pt B},
  pages={346-54}
}
The Gram-positive Corynebacterium glutamicum is auxotrophic for biotin. Besides the biotin uptake system BioYMN and the transcriptional regulator BioQ, this bacterium possesses functional enzymes for the last three reactions of biotin synthesis starting from pimeloyl-CoA. Heterologous expression of bioF from the Gram-negative Escherichia coli enabled biotin synthesis from pimelic acid added to the medium, but expression of bioF together with bioC and bioH from E. coli did not entail biotin… CONTINUE READING
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