Engineering autoactivating forms of matrix metalloproteinase-9 and expression of the active enzyme in cultured cells and transgenic mouse brain.

@article{Fisher2002EngineeringAF,
  title={Engineering autoactivating forms of matrix metalloproteinase-9 and expression of the active enzyme in cultured cells and transgenic mouse brain.},
  author={Katherine E Fisher and Qing Fei and Ellen R. Laird and Jeffrey L. Stock and Melanie R Allen and Barbara G. Sahagan and Christine A. Strick},
  journal={Biochemistry},
  year={2002},
  volume={41 26},
  pages={8289-97}
}
Matrix metalloproteinases (MMPs) are hypothesized to play an important role in the pathogenesis of several central nervous system disorders. Increased levels of expression of MMP-9 (gelatinase B) and MMP-2 (gelatinase A) have been observed in Alzheimer's disease, stroke, multiple sclerosis, and amyotrophic lateral sclerosis. This suggests an aberrant regulation of MMPs that could lead to inappropriate expression of MMP activity. To allow us to evaluate the effect of increased levels of active… CONTINUE READING

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