Engineering animal models of dystonia.

  title={Engineering animal models of dystonia.},
  author={Janneth Oleas and Fumiaki Yokoi and Mark P. DeAndrade and Antonio Pisani and Yuqing Li},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  volume={28 7},
Dystonia is a neurological disorder characterized by abnormal involuntary movements that are prolonged and often cause twisting and turning. Several genetically modified worms, fruit flies, and rodents have been generated as models of genetic dystonias, in particular DYT1, DYT11, and DYT12 dystonias. Although these models do not show overt dystonic symptoms… CONTINUE READING