Engineering and characterization of a murine MHC class II-immunoglobulin chimera expressing an immunodominant CD4 T viral epitope.

@article{Casares1997EngineeringAC,
  title={Engineering and characterization of a murine MHC class II-immunoglobulin chimera expressing an immunodominant CD4 T viral epitope.},
  author={Sofia Casares and Constantin A. Bona and Teodor D. Brumeanu},
  journal={Protein engineering},
  year={1997},
  volume={10 11},
  pages={
          1295-301
        }
}
T cells recognize peptides derived from the processing of proteins by antigen presenting cells (APCs) in association with the major histocompatibility complex (MHC) molecules. We have engineered a murine MHC class II antigen presenting molecule consisting of the extracellular domains of I-E(d)alpha and I-E(d)beta chains to which the CD4 T cell immunodominant epitope HA110-120 of the hemagglutinin (HA) of the A/PR/8/34 influenza virus was covalently linked at the N-terminus of the I-E(d)beta… CONTINUE READING

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