Engineering and Characterization of Functional Human Microvessels in Immunodeficient Mice

  title={Engineering and Characterization of Functional Human Microvessels in Immunodeficient Mice},
  author={Jacques Eduardo N{\"o}r and Martin C. Peters and Joan B Christensen and Michelle M Sutorik and Stephanie Linn and Mohamed K Khan and Christina L Addison and David J Mooney and Peter J. Polverini},
  journal={Laboratory Investigation},
Current model systems used to investigate angiogenesis in vivo rely on the interpretation of results obtained with nonhuman endothelial cells. Recent advances in tissue engineering and molecular biology suggest the possibility of engineering human microvessels in vivo. Here we show that human dermal microvascular endothelial cells (HDMEC) transplanted into severe combined immunodeficient (SCID) mice on biodegradable polymer matrices differentiate into functional human microvessels that… CONTINUE READING


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